Karla M Neugebauer, PhD

Professor of Molecular Biophysics and Biochemistry and of Cell Biology

Departments & Organizations

Center for RNA Science and Medicine, Yale

Faculty Research

Yale Cancer Center: Genomics, Genetics, and Epigenetics

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS): DNA Dynamics and Transcriptional Regulation; RNA Processing and Ribonucleoprotein Machines | Molecular Cell Biology, Genetics and Development: Cell Biology; Genetics and Genomics; Molecular Mechanisms; Nuclear Dynamics; Quantitative/Systems Biology; RNA Biology

Office of Cooperative Research

Biography

  • 2001 – 2013 Research Group Leader, Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany
  • 1999-2001 Assistant Professor, Department of Neurology, University of Washington Medical School, Seattle, WA
  • 1998-1999 Staff Scientist at Fred Hutchinson Cancer Research Center, Seattle WA
  • 1996-1997 Postdoc at EMBL in Heidelberg Germany
  • 1991-1996 Postdoc at Fred Hutchinson Cancer Research Center, Seattle WA

Education & Training

PhD University of California-San Francisco, Neuroscience (1990)
BS Cornell University, Biology/Neuroscience (1984)

Honors & Recognition

  • Mid-Career Achievement AwardRNA Society (2017)

  • CASE MemberConnecticut Academy of Science and Engineering (2016)

  • EMBO MemberEuropean Molecular Biology Organization (2012)

Professional Service

  • MB&B committee on Climate and Diversity (2016 - 2017)

  • Faculty Advisory Committee (Yale Medical School) (2015 - 2016)

  • Committee on Admissions and Financial Aid (Yale College) (2014 - 2017)

  • Scholar Awards Committee (2013 - 2015) member

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Contact Info

Karla M Neugebauer, PhD
Mailing Address
333 Cedar St
New Haven, Connecticut 06520

Neugebauer Lab

Higher order organization and functional links among gene expression machineries.

Illustration of the nucleus and cytoplasm of a eukaryotic cell containing nonmembrane-bound cellular bodies, such as nucleoli, Cajal bodies, the histone locus bodies, and P-bodies. Cellular bodies promote molecular interactions by increasing the local concentration of factors. They are often linked to transcription of particular genes (nucleolus: rDNA genes; CB: snRNA genes; histone body locus: histone genes). Similarly, individual machines are rich in RNA polymerase, spliceosomes, RNA-binding proteins and other factors that communicate with one another during gene regulation.